Assembloids: The next frontier in 3D tissue modeling for human biology
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Apr-2025 06:08 ET (24-Apr-2025 10:08 GMT/UTC)
A breakthrough in biomedical research is reshaping the way scientists study human biology. Assembloids—advanced 3D tissue models that integrate multiple organoids or specialized cell types—are unlocking new dimensions in developmental biology, disease modeling, and drug discovery by more closely mimicking the complex cellular interactions within human tissues. A recent review categorizes assembloids into four key assembly strategies—multi-region, multi-lineage, multi-gradient, and multi-layer—each designed to better simulate complex biological processes with unprecedented accuracy. By bridging the gap between simplified organoids and the intricate architecture of human tissues, assembloids are poised to transform our understanding of health and disease.
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