In a pioneering study, study, researchers have demonstrated that metformin, a common diabetes drug, can slow the growth of skin tumor organoids. This research highlights metformin’s role in modulating immune pathways, offering new possibilities for treating dermatofibrosarcoma protuberans (DFSP), a rare skin cancer. By targeting the tumor’s immune microenvironment, metformin presents a promising avenue for personalized cancer therapies. The findings mark a significant advance in the development of targeted treatments for skin cancer, suggesting that metformin could be repurposed to enhance immune responses and improve patient outcomes.

PDC-SiOC is a highly promising microwave-absorbing material characterized by high temperature resistance, lightweight, high strength, and extremely low cost. The weak electromagnetic wave (EMW) attenuation capacity and poor flexibility of single precursor-derived SiOC ceramic significantly limit its further applications. This study employs a simple electrospinning technique to fabricate SiOC nanofibers with three-dimensional porous structure. The introduction of Co and Ti promotes the nanostructuring of fibers and introduces polarization interfaces and defects, thereby enhancing the polarization loss of the samples. Consequently, the Co/TiO₂/SiOC sample exhibits an effective absorption bandwidth (EAB) up to 8.64 GHz (9.36-18.00 GHz) at a thickness of 3.25 mm, achieving an RL_min value of -66.00 dB at 17.11 GHz. Meanwhile, the nanofiber mats also demonstrate excellent thermal insulation performance (thermal conductivity ranging < 0.041 Wm^-1k^-1), remarkable flexibility (resistance change rate after 1500 cycles of 180° bending test is less than 4%), and impressive resilience performance (residual strain < 12% after 500 cycles under 60% strain conditions). The successful preparation of such multi-functional nanofiber mats makes it promising perspectives for the application of thermal and microwave protection.

Arc wire-based Direct Energy Deposition (DED) is an essential additive manufacturing process known for its high deposition rate and cost-effectiveness. Utilizing an electric arc for heat and metal wire as feed material, it builds 3D metal parts layer by layer. However, defects like residual stresses, porosity, and cracking can arise from the complex thermal cycles. This paper reviews the DED process, focusing on microstructure evolution and mechanical property enhancement. It discusses methods for controlling heat input and various treatments to mitigate defects, aiming for high-quality, defect-free components. Recommendations for future DED advancements are also provided.

The tube spinning process has attracted much attention because of its simple tooling and good surface finish. In the spinning process, a large local plastic deformation will occur, resulting in different changes in the internal and external microstructure of the tube, thus effectively improving its mechanical properties. Therefore, there is a strong correlation between the spinning parameters and the yield strength, elongation and material microstructure of the tube. At present, with the further research, the spinning process of composite tube and the spinning composite process combined with other processes have received the favor of many researchers. This paper mainly introduces the element diffusion and interface bonding mechanism in the spinning process of composite tube and the latest development and trend of composite spinning process. The challenges and prospects of the development of tube spinning process are put forward, and the future research direction was pointed out.