23-Feb-2026
Human liver tissue cell architecture reconstructed in 3D at a cellular level
University of Washington School of Medicine/UW MedicinePeer-Reviewed Publication
Never-before-seen 3D reconstructions of human liver tissue have been created at a cellular level. The details capture the spatial microstructure of multiple lobes of this multitasking organ. The reconstructions show how cirrhosis rearranges this intricate architecture and thereby alter the organ's biological activities. In addition, 3D liver maps with a high degree of cellular detail are critical to someday realizing the dream of bioprinting new organs for transplantation.
- Funder
- NIH/National Institute of Diabetes and Digestive and Kidney Diseases, NIH Environmental Pathology and Toxicology Training Grant, NIH/National Center for Advancing Translational Sciences (NCATS), NIH/National Institute of General Medical Sciences, U.S. National Science Foundation, Howard Hughes Medical Institute, NIH/National Institute on Alcohol Abuse and Alcoholism, Advanced Research Projects Agency for Health