Monoclonal antibodies like etesevimab have lost efficacy against Omicron subvariants, necessitating innovative solutions. George Fu Gao's team developed BAADesign, a strategy combining structural analysis, computational design, and experimental validation to restore antibody activity. Using this method, they reengineered etesevimab into CB6-IV, achieving broad-spectrum neutralization against Omicron subvariants.

High-entropy carbides (HECs) exhibit exceptional mechanical properties and ultrahigh thermal stability, making them promising materials for high-temperature extreme environments, such as hypersonic vehicles and nuclear reactors. The fabrication of complex-shaped components for these applications involves the HECs joints and requires these joints capable of withstanding extreme service temperatures. However, developing such joints presents significant challenges: the stability and sluggish diffusion characteristics of HECs hinder solid-phase diffusion, while using liquid alloys at bonding interfaces typically introduces low-melting-point compounds that compromise thermal durability. Consequently, developing HEC joints with superior high-temperature endurance remains a critical challenge in materials engineering.

Timely monitoring abnormal gaits of teenagers is crucial for their physical health and development. Triboelectric nanogenerators (TENGs) are widely used in the wearable field. Choosing high-performance and safe triboelectric materials to monitor abnormal gaits remains challenging. Polyoxometalates (POMs) nanomaterials can effectively serve as triboelectric materials due to rich surface morphology and large specific surface area. The team designed a TENG using POMs nanorods as triboelectric materials by changing the morphology of POMs, achieving an improvement in TENG performance. The optimized TENG has achieved significant results in gait monitoring of teenagers, promoting research in this field.

MXene, as a rising star among two-dimensional electromagnetic wave materials, faces urgent challenges in addressing its self-stacking issue and regulating its conductivity. Herein, a micro-macro collaborative design strategy was proposed to regulate heterogeneous interface engineering in MXene-based absorbers. Biomass-based cotton was introduced as three-dimensional (3D) framework for constructing a porous structure, TiO₂ was in-situ generated and nitrogen atom was doped on Ti₃C₂T_x MXene to regulate its dielectric properties, a 3D N-doped carbon fiber/MXene/TiO₂ (N-CMT) nano-aerogel was successful constructed. The synergistic effects of diverse components and structural designs, porous frameworks and TiO₂ lattice contraction can significantly adjust the density of the conductive network and create abundant heterogeneous interfaces, as well as the lattice defects induced by nitrogen atom doping can enhance polarization loss, ultimately leading to the excellent microwave absorption performance of 3D N-CMT nano-aerogels. The optimized N-CMT 30% aerogel exhibited a minimum reflection loss of −72.56 dB and an effective absorption bandwidth of 6.92 GHz at 2.23 mm. These results demonstrate that 3D N-CMT nano-aerogel relying on interface engineering design exhibits significant potential in the field of electromagnetic protection, providing an important reference for future efficient absorbers.

Generative artificial intelligence (GenAI) tools, which mimic human-like conversations have the capacity to respond to questions, admit mistakes, and provide instantaneous linguistic feedback. A new study among college students in China has revealed the technological, educational, and social applications, as well as the limitations, of GenAI feedback. This study highlights the potential of GenAI feedback to enhance L2 writing outcomes, despite its current shortcomings.

A new study uncovers crucial insights into the gene interactions linked to Alzheimer's disease (AD), revealing how amyloid-beta accumulation affects gene dynamics across different brain regions and age groups.