Hypertrophic cardiomyopathy (HCM) is a prevalent inherited cardiac disease marked by left ventricular hypertrophy, often due to sarcomere gene mutations. Using transcriptomic, DNA methylomic, and chromatin accessibility analyses, this study offers a high-resolution multi-omics map of HCM cardiac tissues. The findings highlight a fetal-like gene reprogramming in HCM hearts, particularly involving sarcomeric and metabolic gene suppression and extracellular matrix gene activation. Furthermore, the study identifies SP1 and EGR1 transcription factors as potential therapeutic targets, validated through experimental inhibition in an HCM mouse model, which mitigated pathological features.

With the successive release of the CONSORT extensions for acupuncture, moxibustion, cupping, and Tuina/massage, this review aims to assess the reporting characteristics and quality of randomized controlled trials (RCTs) based on these specific guidelines. A comprehensive review was conducted by searching multiple databases, including Embase, Ovid MEDLINE(R), All EBM Reviews, AMED, CNKI, VIP Chinese Medical Journal Database, and Wanfang Data, for publications from January 1 to December 31, 2022. Two reviewers independently evaluated the eligibility of the records, extracted predetermined information, and assessed the reporting based on the STRICTA, STRICTOM, STRICTOC, and STRICTOTM checklists. Among the included 387 studies (acupuncture, 213; Tuina/massage, 85; moxibustion, 73; cupping, 16), the overall reporting compliance averaged 56.0%, with acupuncture leading at 62.6%, followed by cupping (60.2%), moxibustion (53.1%), and Tuina/massage (47.9%). About half of the evaluated items showed poor reporting (compliance rate < 65%). Notably, international journals demonstrated significantly higher reporting quality than Chinese journals (P < 0.05). Although acupuncture trials had relatively higher compliance rates, deficiencies persist in reporting non-pharmacological therapies of Chinese medicine, particularly in areas like treatment environment details and provider background information.

Researchers from Xiangtan University and the China Institute of Atomic Energy have developed hybrid plastic scintillators with enhanced optical clarity, mechanical strength, and cost-efficiency, offering a safer, more durable alternative for radiation detection in industries like nuclear safety, border security, and medical imaging.

The team proposed a sequential recommendation framework named TailRec that enables contextual information of tail item well leveraged and greatly improves its corresponding representation. In contrast to previous works, this approach allows for the mining of contextual information from cross sequence behaviors to boost the performance of sequential recommendations. Such a light contextual filtering component is plug-and-play for a series of SRS models.

A research team from the Southern University of Science and Technology has developed an electrochemically stable and ultrathin polymer-based solid electrolytes. Enhancing interfacial contact with lithium metal anode and constructing lithium-ion pathways, this innovative approach exhibits over 2100 hours of stable battery cycling in Li-symmetric cells. The study may offer a new approach for fabricating ultrathin solid electrolytes and provide insights into the mechanisms of dendrite-free formation, guiding the development of high-performance solid electrolytes.

Craniopharyngioma has long been a daunting challenge for neurosurgeons and endocrinologists alike. Chinese researchers recently revealed new insights on the growth of craniopharyngioma and identified a potential therapeutic treatment. Understanding this complex tumor’s growth mechanism and identifying a potentially effective, non-invasive medication to treat it mark a significant step forward.

In a paper published in the National Science Review, a team of Artificial Intelligence (AI) scholars comprehensively reviews the latest advancements of one the most cutting-edge research realms, Multimodal Large Language Models (MLLMs). The paper not only summarizes the essential components of MLLMs, including architecture, training, data, and evaluation, but also provides an in-depth discussion of relevant research topics, such as Multimodal Hallucinations, Multimodal In-context Learning, Multimodal Chain-of-Thought, and LLM-Aided Visual Reasoning.

This review provides progress in the development of pTau targeting therapies and discusses their advantages and limitations.

In a paper published in Science Bulletin, Researchers employed a self-assembled monolayer of 4-(9H-carbazol-9-yl)phenylboronic acid (4PBA) as hole-selective contact providing a chemically stable buried interface for Sn-Pb perovskite solar cell. 4PBA can formed a robust and low-corrosive anchoring on the FTO and reduced the energy level mismatch between the perovskite and the substrate through its substantial dipole moment, providing a rapid extraction pathway for hole. Additionally, 4PBA enhanced the interfacial contact between the perovskite and the substrate, improving the crystallization quality of the perovskite, and prevented acid-induced degradation of Tin-Lead perovskite caused by PEDOT:PSS, further minimizing defects in the perovskite device. This strategy offered insights into developing high-efficiency, stable Tin-Lead perovskite solar cells with energy band alignment and interfacial chemical stability.

In a recent paper published in Science Bulletin, researchers discovered for the first time that stable polymeric nitrogen samples could be prepared at ambient pressure using a simple one pot thermal treatment technique. High resolution Raman spectroscopy measurements revealed a strong characteristic vibrational peak of N-N single bonds, indicating the successful preparation of polymeric nitrogen materials composed of N-N single bonds in the polymerized sample. The approach is promising for further scale up production of polymeric nitrogen materials.