News from China
Updates every hour. Last Updated: 24-Apr-2025 23:08 ET (25-Apr-2025 03:08 GMT/UTC)
Breast cancer battle: Precision subtyping leads to personalized treatment
China Anti-Cancer AssociationPeer-Reviewed Publication
- Journal
- Cancer Biology & Medicine
Simultaneous acceleration of sulfur reduction and oxidation on bifunctional electrocatalytic electrodes for quasi-solid-state Zn-S batteries
Science China PressIn a paper published in SCIENCE CHINA Chemistry, a bifunctional electrocatalytic sulfur matrix that simultaneously accelerates sulfur reduction and ZnS oxidation is proposed to realize a highly efficient Zn-S cell. It is revealed that the N-heteroatom hotspots are more favorable for facilitating the conversion of S to ZnS while the CoO nanocrystal substantially lowers the ZnS activation energy barrier thereby suppressing the formation of disproportionation species (e.g., SO42−) and accumulation of inactive ZnS.
- Journal
- Science China Chemistry
PolyU project develops a library of polarized vdW heterobilayers for advancing computing applications supported by NSFC / RGC Collaborative Research Scheme
The Hong Kong Polytechnic UniversityiEnergy has been officially included in the ESCI
Tsinghua University PressGrant and Award Announcement
iEnergy has been officially included in the Emerging Sources Citation Index (ESCI) by Web of Science, a leading global provider of scientific and scholarly research information.
Characteristics of axisymmetric inward turning detonation wave: A new possibilities for detonation in the internal channel
Tsinghua University PressPeer-Reviewed Publication
Standing detonation engines have emerged as the prime power source for highspeed vehicles. While current detonation flow field designs have demonstrated their effectiveness, several hurdles still remain. These include the limited geometric utilization of the combustion chamber and the lack of seamless integration with existing highspeed aerodynamic designs. Selecting the right basic detonation flow field is paramount to enhancing the performance and refining the geometric design of standing detonation vehicles.
- Journal
- Chinese Journal of Aeronautics
Dual-phase medium-entropy diboride-carbide ceramics with metal element exchange during sintering
Tsinghua University PressPeer-Reviewed Publication
Multiphase composition design and entropy engineering control are promising strategies to improve the properties of ultra-high temperature ceramics (UHTCs). In this study, spark plasma sintering was used to prepare fully dense dual-phase (Zr, Hf, Ta)B2-(Zr, Hf, Ta)C ceramics from self-synthesized equimolar medium-entropy diboride and carbide powders. The obtained ceramics comprised two distinct solid solution phases, the Zr-rich diboride phase and the Ta-rich carbide phase, indicating metal element exchange occurred between the starting equimolar medium-entropy diboride and carbide during sintering. The chemical driving force originating from the metal element exchange during the sintering process is considered to promote the densification process of the ceramics. The metal element exchange between the medium-entropy diboride and carbide phase significantly increased Young’s modulus of the dual-phase ceramics. Owing to the mutual grain-boundary pinning effect, fine-grained dual-phase ceramics were obtained. The dual-phase medium-entropy 50 vol.% (Zr, Hf, Ta)B2-50 vol.% (Zr, Hf, Ta)C ceramics with the smallest grain size exhibited the highest hardness of 22.4 ± 0.2 GPa. It is inferred that optimized comprehensive properties or performance of dual-phase high-entropy or medium-entropy UHTCs can be achieved by adjusting both the volume content and the metal element composition of the corresponding starting powders of diborides and carbides.
- Journal
- Journal of Advanced Ceramics
Discovery of β‐nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens
Tsinghua University PressPeer-Reviewed Publication
Quorum sensing (QS) is a bacterial density-dependent gene expression mechanism that involves the binding of receptors and autoinducers to govern pathogenic bacteria (swarming, swimming, and biofilm formation) by producing virulence factors, which can diminish antibiotic efficacy. This novel concept may broaden the usage of antibiotics while preventing antimicrobial resistance (AMR) in humans. So in this investigation, the authors developed, synthesized, and evaluated β-nitrostyrenes derivatives to identify a new class of Quorum sensing inhibitors (QSIs) against S. marcescens. Through QS inhibitory screening of β-nitrostyrene derivatives, m-NPe was identified as a potent QSI against S. marcescens, and it could be employed in clinical trials to partially restore or increase drug sensitivity. Therefore, m-NPe has the potential to be developed as an effective and efficient QSI and antibiofilm agent for treating microbial infection and can evolve as an alternative clinical drug in the future.
- Journal
- mLife
Application of heavy-ion irradiation mutagenesis to improve the production efficiency of the antifungal drug micafungin
Tsinghua University PressPeer-Reviewed Publication
Micafungin is a semisynthetic echinocandin antifungal agent derived from fungal natural product FR901379 produced by Coleophoma empetri, which faces challenges in rational transformation of industrial strains due to poor chassis performance and unclear high-yield mechanisms. Recently, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences and Institute of Modern Physics Chinese Academy of Sciences cooperated on heavy-ion irradiation mutagenesis, significantly improving the production performance of FR901379 (253.7%), and analyzed the heavy-ion irradiation damage repair mechanism and high-yield mechanism. This study not only provides better chassis cells and theoretical guidance for subsequent metabolic engineering modifications, but also provides a reference for the application of heavy-ion irradiation in filamentous fungal breeding.
- Journal
- Mycology: An International Journal on Fungal Biology
Topographic complexity: A blueprint for biodiversity conservation
Tsinghua University PressPeer-Reviewed Publication
- Journal
- Forest Ecosystems