A new method for efficient synthesis of anti-cancer drugs
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Apr-2025 09:08 ET (30-Apr-2025 13:08 GMT/UTC)
The Horner–Wadsworth–Emmons (HWE) reaction is commonly used in organic chemistry to synthesize conjugated aldehydes. However, traditional HWE reaction methods sometimes have inconsistent (E)- and (Z)-selectivity, and (E)-isomers of conjugated carbonyl compounds are important for the synthesis of hynapene analogues, which have anti-cancer properties. Researchers have developed a new HWE reaction using a Weinreb amide–type HWE reagent, featuring high robustness, scalability, and (E)-selectivity. Additionally, its key intermediate can be isolated and is exceptionally stable.
The Israel-Hezbollah conflict has deepened an education crisis in which children have lost up to 60% of schooling in six years, a new study shows. Even if the current ceasefire holds, the research indicates that there is a lack of forward planning for education recovery that could mean more children are left behind, and inequalities become further entrenched.
A new research collaboration between the K’ómoks First Nation and Simon Fraser University highlights how Indigenous cultural heritage policies can protect archaeological sites threatened by development, given inadequate provincial heritage protection laws.
The study, published in the journal Frontiers in Environmental Archaeology, spotlights K’ómoks First Nation’s cultural heritage policy – developed to abate the onslaught of archaeological site destruction in their southern core territory (the Comox Valley, Hornby and Denman Islands) – and the need for provincial legislation and municipal policies to implement Nation-led archaeological site protection.
From devastating wildfires and landslides to droughts and extreme heat waves, climate-related events disrupt the lives of communities around the world. How these events impact the health of Los Angeles’s vulnerable communities is a question numerous USC researchers are working to solve. The National Institutes of Health (NIH) has awarded $4.1 million to a USC-led initiative to build a community of transdisciplinary scientists and a robust infrastructure with the goal of advancing solution-oriented climate change adaptation and health research. The center is called CLIMA, short for the CLIMAte-related Exposures, Adaptation and Health Equity Center. CLIMA researchers have been collaborating with USC Dornsife Public Exchange and the City of Los Angeles Climate Emergency Mobilization Office (CEMO) to build a visual mapping tool called a StoryMap, which can add narrative context to the city and county’s extreme heat challenges. By combining Geographic Information System (GIS) mapping with accessible climate storytelling, the StoryMap can inform the public about the risks associated with extreme heat, as well as provide resources for and information regarding the City of Los Angeles’ #HeatRelief4LA campaign.