Psychedelics and non-hallucinogenic analogs work through the same receptor, up to a point
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Updates every hour. Last Updated: 4-Aug-2025 08:11 ET (4-Aug-2025 12:11 GMT/UTC)
Cannabis use is gaining popularity in the United States, driven by growing legalization, public acceptance and diverse methods of consumption.
More people than ever before support its legal medicinal and recreational use, and more adults — mainly men — are turning to cannabis for relief from physical and mental health symptoms.
Now, health behavior experts from the Texas A&M University School of Public Health, along with collaborators from three other universities, have taken a closer look at this dual use among Hispanic and non-Hispanic Black men living with chronic health conditions.
In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments. The study, published in the August 1 online issue of Science Advances, focuses on the 5-HT1A serotonin receptor, a major player in regulating mood and a common target of both traditional antidepressants and newer therapies such as psychedelics. Despite its clinical importance, this receptor has remained poorly understood, with many of its molecular and pharmacological properties largely understudied—until now.