Time-restricted feeding (TRF) benefits metabolic health, yet sex differences in its effects are often overlooked. A study by Sichuan Agricultural University published in Life Metabolism reveals TRF impacts liver metabolism differently in males and females. TRF promotes amino - acid - driven lipid synthesis in females and suppresses lipid production in males, linked to liver ERα. Experiments with knockout models confirm ERα’s role. The research uncovers molecular mechanisms, aiding personalized nutrition and metabolic disorder interventions.

This research provides a robust framework for optimizing the operation of electric grids with integrated PEM electrolyzers. By accurately modeling the electrolyzer's performance and incorporating it into the grid dispatch strategy, the study demonstrates how to enhance grid flexibility, reduce costs, and increase renewable energy utilization. The findings are particularly relevant for regions with high renewable energy penetration and offer practical insights for grid operators and policymakers aiming to achieve sustainable energy systems.

Inherited retinal degeneration (IRD) encompasses various disorders characterized by progressive loss of retinal photoreceptor cells, ultimately leading to vision loss and blindness. Among the numerous genetic factors implicated in IRD, mutations in the CRB1 gene stand out as significant contributors to severe forms of retinal degeneration, including retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). Recent research has unveiled a novel mechanism linking CRB1 mutations to retinal degeneration through bacterial translocation from the gut to the eye, opening up promising therapeutic avenues.

The CRB1 gene encodes a transmembrane protein crucial for maintaining the integrity of epithelial barriers in both the retina and the colon. In the retina, CRB1 plays a vital role in the structure and function of photoreceptor cells and the blood-retinal barrier (BRB). Recent studies have shown that CRB1 is also expressed in colonic enterocytes, where it maintains the integrity of adherens junctions (AJ) and the colonic epithelial barrier. Mutations in CRB1 disrupt these barriers, creating a "leaky gut" and "leaky retina" phenomenon that allows gut bacteria to translocate to the retina.

This study proposes a one-step hydrothermal method to fabricate intergrowth Bi₇Ti₄NbO₂₁ with high ferroelectric polarization. The interlayer lattice mismatch and periodic mechanical stress lead to increased tilting along the a-axis and rotation angle in the a-b plane of Ti/NbO₆ octahedra within perovskite-like layers, serving as the main reason for increased polarization compared to the parent phase. Notably, Bi₇Ti₄NbO₂₁ exhibits excellent piezo-photocatalytic CO₂ reduction activity, with impressive CO generation rate of 426.97 µmol g⁻¹ h⁻¹.

Immunodeficiency disorders linked to cytoskeleton defects are rare and complex, often presenting with diverse clinical features. This case report highlights a patient with recurrent eosinophilia and a novel homozygous ARPC1B mutation, expanding our understanding of genetic factors in immune-related conditions.

Lung cancers with SMARCA4 deficiency are rare, typically showing aggressive behavior and poor prognosis. These tumors rarely harbor common targetable oncogenes like EGFR, ALK, or ROS1. This case report details a nonsmoking middle-aged woman with SMARCA4-deficient non-small cell lung cancer (NSCLC) and rare EGFR mutations who achieved significant tumor response with afatinib.

Polycystic ovary syndrome (PCOS) represents a significant health concern for women of reproductive age, manifesting as a complex endocrine disorder with diverse clinical presentations. Characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology, PCOS affects 5% to 20% of women and stands as a leading cause of anovulatory infertility. The pathophysiology of PCOS involves abnormal folliculogenesis, resulting in arrested follicular development and the accumulation of small antral follicles. This follicular arrest is accompanied by mitochondrial dysfunction and oxidative stress, contributing to poor oocyte quality and developmental potential. Recent research has highlighted the potential role of neurotensin (NTS), a gut-brain peptide, in the regulation of ovulation and its dysfunction in PCOS.

Atopic dermatitis (AD) is a chronic inflammatory skin disease with high prevalence, especially in children. Current treatments like topical glucocorticoids have limitations due to side effects and resistance. Traditional Chinese medicine (TCM) offers alternative solutions, with Qin-Zhu-Liang-Xue (QZLX) decoction showing efficacy in AD treatment. This study explores the mechanisms of QZLX using network pharmacology and evaluates its clinical effects through trials and animal experiments.

Ovarian cancer, a leading cause of death among gynecological malignancies, has a poor prognosis and low 5-year survival rate, necessitating new therapeutic strategies. CDK4/6 inhibitors show promise but their efficacy varies, highlighting the need for biomarkers. This study explores TRIM4's role in ovarian cancer's response to CDK4/6 inhibitors, revealing that TRIM4, an E3 ligase, influences sensitivity by modulating hnRNPDL and CDKN2C levels.

This study explores the protective effects of trigonelline against spinal cord injury in rats.