AI-powered precision prediction of immunotherapy response in colorectal cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Apr-2025 10:08 ET (24-Apr-2025 14:08 GMT/UTC)
The immune-related genes in the colorectal cancer (CRC) microenvironment are closely associated with patient prognosis and the efficacy of immunotherapy. Professor Wang's group established a novel machine learning-based model to predict prognosis and immunotherapy responses in colorectal cancer (CRC) patients. The authors integrated clinical and transcriptomic data using machine learning techniques and established the Immune Response-related Risk Score (IRRS) model in CRC. The IRRS model is based on 13 core immune-related genes from machine learning techniques, and demonstrates strong associations with tumor progression, immune infiltration, and therapy response. The IRRS model outperforms several existing tools, offering a more accurate and clinically relevant approach to personalized cancer treatment.
Magnetic soft robots, providing excellent flexibility and precise control, are transforming fields from surgery to environmental exploration. Focusing on the relationship between structural configurations and locomotion modes of magnetic soft robots, a new review article in FlexTech systematically summarizes the material composition, fabrication methods, locomotion modes, and applications of existing magnetic soft robots. Furthermore, this article also analyzes and discusses the current challenges and future development directions of structured magnetic soft robots.
Biliary tract infections (BTI), often linked to structural abnormalities like bile duct stones, pose significant treatment challenges due to drug-resistant bacteria like Pseudomonas aeruginosa. Phage therapy, which uses viruses to target bacteria, has emerged as a promising solution. This study by researchers from Fudan University and Army Medical University, published in hLife, reported the first successful use of personalized phage therapy for chronic BTI caused by multidrug-resistant P. aeruginosa. An 88-year-old patent with recurrent infections underwent phage therapy after traditional treatments failed. A customized phage cocktail was administered, leading to symptom improvement and reduced bacterial load. However, phage-resistant strains emerged, prompting a second round of therapy with a different phage, which further alleviated symptoms. Genomic analysis revealed bacterial mutations contributing to resistance. This study highlights the potential of phage therapy for treating drug-resistant infections, though challenges like bacterial heterogeneity and biofilm formation remain. Future research aims to optimize phage therapy strategies for better outcomes.
A research team led by Professor Xiaonan Wang from Tsinghua University has published a comprehensive review on AI-enhanced multi-scale smart systems for decarbonizing the chemical industry. The study, featured in Technology Review for Carbon Neutrality, explores innovations from micro-level materials discovery to macro-level industrial park optimization, highlighting how intelligent approaches enhance efficiency, sustainability, and carbon neutrality. It also examines cross-scale modeling for complex chemical processes and identifies key challenges such as data management and industrial integration. The review concludes with future research directions, advocating interdisciplinary strategies to drive the industry toward a greener and more efficient future.
A study from East China Normal University explores how Large Language Models (LLMs) can revolutionize education by automating teaching tasks. It highlights two key applications: generating customized materials and streamlining assessment. While LLMs reduce educators’ workload, human oversight remains crucial. The research suggests a collaborative model where teachers act as orchestrators and LLMs serve as assistants, ensuring AI integration enhances personalized education while maintaining instructional quality and adaptability.
A cutting-edge breakthrough in zero-sodium-excess solid-state batteries may reshape the energy storage landscape. This innovative study introduces a novel interphase design to address the persistent challenges of low energy density and poor interfacial stability in sodium-ion batteries, offering a solution poised to revolutionize next-generation energy storage systems.
A novel study has unveiled a transformative advancement in perovskite solar cells through bilayer interface engineering. This innovative method integrates 2D/3D perovskites with a dipole layer, achieving a remarkable leap in power conversion efficiency and overcoming critical challenges of scalability and stability in large-area solar modules.
A cutting-edge study has made significant advancements in battery lifetime prediction by utilizing transfer learning, a sophisticated approach that transfers knowledge across different data domains. This innovation enhances the accuracy of battery life predictions, a critical factor for ensuring product quality and accelerating progress in energy storage technologies.
Social-emotional ability serves as a critical human foundation for sustainable societal development. While researchers have focused on enhancing primary and secondary school students' social-emotional skills, the development of university students' social-emotional ability has been overlooked. This study examines the current state of college students' social-emotional abilities. It identifies that these skills are significantly influenced by various factors, including education level, gender, university type, geographic origin, family background, and teacher–student relationships, which are found to significantly affect college students' social-emotional ability.