In a paper published in Science Bulletin, researchers developed a selective DNA aptamer-based PROTAC targeting p53-R175H, a common hotspot mutant with dominant-negative and oncogenic activity. They found that the PROTAC displayed significant anti-tumor activity against cancer cells carrying the p53-R175H mutation and synergistically improved the sensitivity of these cells to cisplatin.

This study demonstrated that the activation mode of an ancient type of ion channel,TRPM2, by ADPR and Ca²⁺ evolved through at least three identifiable stages from a simple activation mode to an intermediate one and then to a complicated and coordinated one. A novel gating mode in fish TRPM2 proteins was identified, representing an evolutionary intermediate. Important permissive changes at a specific position were also identified, which occurred during the transition from water to land in vertebrates, indicating the origin of the NUDT9-H domain's dependence for channel activation by ADPR. The researchers proposed that the environmental oxygen level may facilitate the TRPM2 channels to acquire a more precisely regulated, coordinated activation mechanism. This study sheds light on how species adapt to their environments at the protein level.

A recent work provides a strategy that combines electrocatalyst design with an electrolysis technique to achieve remarkable performance in neutral HMFOR.

In a paper published in Science Bulletin, PDPI/CNTs nanocomplexes were designed by in situ polymerization of pyromellitic dianhydride and 2,6-diaminoanthraquinone on carbon nanotubes. The optimized PDPI/CNTs showed excellent performance in both K-ion half cells and full cells. Two sets of universal experiments, TOF-SIMS and TEM analysis showed that CNTs-guided polymerization degree modulation is the key to efficiently utilize the active sites for potassium storage.

In a paper published in SCIENCE CHINA Life Sciences, a team from Peking University Third Hospital delves into the sex differences in various functional transition and lineage differentiation events as well as related mechanisms in human pre-gastrulation embryos. Their findings offer foundational insights into the origins of sex differences observed in human fetuses.

In a paper published in Science Bulletin, the authors conducted a nationwide longitudinal study based on photoplethysmography technology from smartwatches. They found that higher ambient temperatures can immediately increase the risk and severity of sleep apnea.

In a recent article published in the National Science Review, based in Beijing, Professor Xingbin Yan and his research team from Sun Yat-sen University introduce a novel concept called the supercapacitor-memristor (CAPistor). This new device leverages non-linear ion transport within the pores of a metal-organic framework, specifically the zeolitic imidazolate framework (ZIF-7).

Recently, Prof. Changqing Chen's group at Tsinghua University has developed a theory to characterize the localized static deformation field of two- and three-dimensional periodic mechanical metamaterials.

The Tea-CUP project (Co-developing Useful Predictions), a joint initiative between UK and Chinese partners, is developed to provide climate service and inform adaptation measures and decision-making within the tea industry.

The corner states in high order topological insulator (HOTI) are strongly localized, which may lead to the enhancement of nonlinear processes. The research team demonstrate first nonlinear fractal photonic HOTI, which supports topological corner states for unexpectedly wide range of coupling strengths, and the localization of threshodless solitons in the system is effectively controlled by adjusting the input beam power. These findings provide a new platform for the study of fractal nonlinear topological insulators.