AMHERST, Mass. — Researchers at the University of Massachusetts Amherst have quantified the impacts of a constellation of social factors on the spread of HIV. Their study, published in Health Care Management Science, found that a hypothetical 100% effective intervention addressing barriers to HIV treatment and care from depression, homelessness, individual and neighborhood poverty, education disparities, lack of insurance and unemployment could reduce the national HIV incidence by 29% over 10 years. The mathematical model, a novel integration of machine learning, probability theory and simulation, is positioned to be an important tool for decision-makers to optimize social programs and will have applications for other diseases. 

CAMBRIDGE, Mass., January 23 --- Insilico Medicine( “Insilico”) , a clinical stage generative artificial intelligence (AI)-driven biotechnology company today announced the first patient has been dosed in the global multicenter Phase I Trial of ISM6331, a novel pan-TEAD inhibitor developed from Insilico's generative chemistry engine Chemistry42, for the treatment of mesothelioma and other solid tumors. Currently, ISM6331 is the leading oncology program among Insilico's wholly owned AI-driven drug discovery pipelines, which was granted orphan drug designation (ODD) by the FDA for the treatment of mesothelioma.

Acupuncture treatment on the DU channel has shown therapeutic effects for Alzheimer’s disease (AD), but the underlying mechanisms are not yet clear. The purpose of this study was to comprehensively observe the protective effects of acupuncture on different brain regions in AD model mice, providing laboratory evidence for clinical acupuncture intervention in AD.

Using computational models, the researchers studied how the brain’s reward-learning system functions in those with depression, especially among individuals experiencing anhedonia, the inability to feel pleasure. By analyzing dopamine-linked responses, they identified unique brain activity patterns that could help predict who is likely to recover.