Review: Foundation models in bioinformatics
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Apr-2025 04:08 ET (28-Apr-2025 08:08 GMT/UTC)
In a paper published in National Science Review, an international team of scientists presented recent advancements in bioinformatics FMs that are applied across a range of downstream tasks, including genomics, transcriptomics, proteomics, drug discovery, and single-cell analysis.
Land subsidence, a significant geological hazard caused by natural and human activities, has become increasingly complex and widespread. Peridynamics, a physical model approach, has been introduced into the land subsidence research domain by the land subsidence research team at Capital Normal University in recent years. This method describes the mechanical behavior of materials by solving spatial integral equations and can conduct integrated modeling of regional land subsidence, including ground fissures. To further improve the land subsidence modeling and simulation, the research team has proposed an innovative strategy that combines peridynamics with deep learning techniques. By integrating neural networks and Gaussian Process Regression, the team optimized boundary conditions, thus significantly improving simulation results. The findings, published in the Journal of Geo-information Science, demonstrate a substantial reduction in prediction errors, offering a promising solution for regional land subsidence modeling.
Utilizing simulation data from the Weather Research and Forecasting Model for a convection event on 23 August 2021, the study analysis revealed that differences in pre-storm wind fields and thermodynamic conditions impeded the movement and cold pool development of the mountainous thunderstorm cluster, while the plain thunderstorm cluster experienced the opposite effect. Ultimately, the clusters merged at the mountain base, where the enhanced cold pool acted analogously to topographical features, strengthening convergence and vertical motion.
Here, Dr. Yuhua Li from Xi'an University of Science and Technology, Prof. Rui Zhu from Shanghai University of Electric Power, Prof. Liqiang Wang from Shanghai Jiao Tong University, and Prof. Lai-Chang Zhang from Edith Cowan University, Australia, co-authored a review in the International Journal of Extreme Manufacturing. This review provides an in-depth introduction to the latest progress in additive manufacturing (AM) technology in the field of biomedical metals. It overviews how AM technology can be applied to the manufacturing of medical implants and focuses on the AM process, microstructure, mechanical properties, and corrosion behavior of a wide range of biomedical materials, such as titanium alloys, stainless steel, cobalt-chromium alloys, and biodegradable alloys. Additionally, the article covers the application of 4D printing technology and artificial intelligence in AM, and discusses practical application cases of AM technology in clinical fields such as orthopedics, dentistry, cardiovascular surgery, and neurosurgery. Finally, the article highlights the challenges and future directions of AM in the manufacturing of medical metal implants.
This review aims to provide a holistic understanding of BFO’s piezocatalytic potential, establishing its role in advancing sustainable catalytic technologies. By presenting a comprehensive overview of BFO’s development, performance, and applications, this manuscript will serve as a critical resource for researchers in the fields of materials science, catalysis, and sustainable technology.
Researchers from South Chian University of Technology have made a significant advancement in the field of water-based adhesives by developing a novel nanocomposite material that combines polyvinyl alcohol (PVA) with 1-nm Keggin-type polyoxotungstate clusters (POTs) carrying four negative charges. This innovative POT-PVA nanocomposite offers a promising solution for creating eco-friendly, versatile, and durable water-based adhesives suitable for a wide range of applications across various industries.
In January 2025, a significant milestone was achieved with the launch of Materials and Solidification, an international journal dedicated to the field of solidification, on SciOpen, an international digital publishing platform developed by Tsinghua University Press.
New research in eGastroenterology identifies the unfolded protein response (UPR) as a crucial mechanism in maintaining intestinal homeostasis and its role in inflammatory bowel disease (IBD) and colorectal cancer. The study provides evidence that chronic ER stress and disruptions in UPR signaling contribute to gut dysfunction, presenting potential therapeutic targets for disease intervention.
A new study explores the potential of fibroblast growth factor receptor (FGFR) antagonists in restoring defective mandibular bone repair in mouse models of osteochondrodysplasia, a group of genetic disorders that impair normal bone development and repair.