Outcomes for advanced hepatocellular carcinoma with pulmonary metastasis: Surgical vs. immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Apr-2025 03:08 ET (26-Apr-2025 07:08 GMT/UTC)
Advanced hepatocellular carcinoma (HCC) with pulmonary metastasis (PM) has a poor prognosis, and optimal treatment strategies remain controversial. This study compared pulmonary metastasectomy and combination immunotherapy with targeted molecular therapies for advanced HCC with pulmonary metastasis, indicating that pulmonary metastasectomy provided longer survival than immunotherapy combined with targeted molecular therapies and has the potential to become the optimal treatment for highly selected HCC patients with resectable PM.
By controlling male fertility, this new gene could help address challenges in the development of highly productive hybrid wheat.
Wheat provides 20% of global food calories, but creating high-yielding hybrid varieties has been challenging due to wheat’s complex genome and self-pollinating nature. Now, researchers from China have identified a key gene—called TaMs6—that encodes an enzyme essential for proper pollen development and affects male fertility in wheat. This discovery provides valuable resources for developing hybrid wheat breeding systems, which would help boost global wheat production to achieve food security.
A research paper by scientists at Beijing Institute of Technology and City University of Hong Kong presented a versatile electrodynamics simulation model designed to analyze the driving forces of partially filled electrodes to optimize the structural parameters of Digital microfluidic chips.
A groundbreaking study from East China Normal University has leveraged AI to analyze classroom teaching patterns across China, revealing that teacher-centered instruction still dominates. This research utilizes a sophisticated AI-powered classroom intelligent analysis system to assess 1,008 recorded Chinese language classes spanning nine grade levels. Usage of AI enables effective systematic analysis of large volumes of classroom data, reducing time and human intervention.
The increasing prevalence of myopia is a global health concern, with high myopia increasing the risk of vision damage. This necessitates the use of artificial intelligence (AI) for early diagnosis, prevention, and management of myopia. Now, a Pediatric Investigation review sheds light on potential applications of AI in the early identification, risk assessment, and prevention of myopia. It further highlights the challenges and current development status of AI technology in the field of myopia.
The team led by Academician Chen Xiaoping from Tongji Hospital, affiliated with the Tongji Medical College of Huazhong University of Science and Technology, in collaboration with several major medical centers, including the Hunan Provincial People's Hospital and the Henan Provincial People's Hospital, conducted a multicenter retrospective study on the controversial issue of whether the caudate lobe of the liver should be routinely resected for patients with hilar cholangiocarcinoma. The results were published in Science China Life Sciences.
Global disparities exist in the burden of cervical cancer. Only 11 out of the 185 countries and regions reported an age-standardized incidence rates (ASIR) lower than the World Health Organization’s target as established by the Cervical Cancer Elimination Initiative. Human Development Index (HDI) was negatively correlated with ASIR and age-standardized mortality rates (ASMR) of cervical cancer. The disease's burden is marked by clear socioeconomic disparities, underscoring the need to develop and evaluate targeted cervical cancer prevention and control strategies for specific regions.
A research team from Southeast University has developed a bio-inspired thermoelectric cement with remarkable Seebeck coefficient via employing interfacial selective immobilization.
Enhanced computing performance is achieved using nanomaterial-based probabilistic-bits with high operational stability.
The India-Asia continental collision and the uplift of the Tibetan Plateau have long been attributed to continuous Cenozoic convergence with two generic assumptions: the ongoing India-Asia collision and the underthrusting of the Indian continent beneath the Tibet hinterland. This study presents a challenge to the two assumptions through an integrative analysis of geological, geophysical and geochemical data, concluding that the two generic assumptions do not stand under close scrutiny and thus are essentially specious in previous studies. The conclusions have great bearing on the formation and evolution of the Himalaya-Tibet tectonic collage.