A multi-institutional team led by The University of Osaka developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team identified a monoclonal antibody called KG2032 that reacts with a certain variant of the HLA-DRB1 molecule. KG2032 CAR T cells displayed strong anti-AML effects in a mouse model, and CAR natural killer cells showed similar results. Clinical trials are currently being planned. 

A research group led by Nagoya University Graduate School of Medicine in Japan has uncovered a potential mechanism linking maternal inflammation to delayed neurodevelopment in infants. The research suggests the role of CD11c-positive microglia—immune cells in the brain crucial for myelination—during infant brain development. Their findings suggest new strategies to mitigate the long-term neurodevelopmental effects of maternal inflammation. 

A well-timed “furrowed face”—a subtle expression we instinctively recognize as “thinking”—can make androids appear less creepy and more relatable to humans.

Self-healing coatings are advanced materials that can repair damage, such as scratches and cracks on their own. Researchers from Waseda University have developed an efficient method for preparing self-healing films consisting of alternating layers of highly cross-linked organosiloxane and linear polydimethylsiloxane (PDMS). Their film is more durable than conventional self-healing PDMS materials, offering superior hardness and greater thermal stability while self-healing at mild temperatures, paving the way for stronger, more reliable, and easier-maintained self-healing materials.

A novel technique to visualize gene-active and gene-repressive DNA regions in living cells, developed by a multi-institutional team based in Japan. The technique reveals the distinct physical properties of chromatin—gene-active euchromatin acts like a liquid, while gene-repressive heterochromatin behaves like a gel—shedding light on their roles in gene expression and DNA replication, with potential implications for understanding genome regulation.

Enhanced westerly winds associated with global warming will strengthen the clockwise circulations and heat transport to the ice sheet in the East Antarctic coastal area.

Rare manuscripts from Kyushu University Library, over 1,000 years old and significant to Japanese language history, are about to be designated as Japan’s Important Cultural Property. More than 300 high-quality images are now freely accessible through the library’s digital archive.

Authoritarian states increasingly use persuasive narratives to shape public opinion in democracies. A new study finds that Japanese voters are broadly susceptible to illiberal narratives from China and Russia, which exert a stronger influence than democratic messaging. Surprisingly, susceptibility was widespread across the population, regardless of political knowledge or beliefs. The findings highlight Japan’s vulnerability to foreign influence operations and underscore the urgent need for countermeasures to protect democratic discourse from manipulative, cognitive warfare.

Plate temperature and water release can explain the occurrence of different types of earthquakes in Guerrera, Mexico. The Kobe University simulation study also showed that the shape of the Cocos Plate is responsible for a gap where earthquakes haven’t occurred for more than a century. The results are important for accurate earthquake prediction models in the region.