Blocking chemokine receptor increases effectiveness of glucocorticoids in multiple myeloma treatment
Peer-Reviewed Publication
Researchers at the VIB-UGent Center for Medical Biotechnology have discovered a promising strategy to improve treatment responses in multiple myeloma patients by blocking a protein that plays a key role in drug resistance. The study, published in Pharmacological Research, offers a potential new strategy to improve outcomes for patients whose disease has become less responsive to standard therapies.
A study by researchers from the Hospital del Mar Research Institute, IIBB-CSIC-IDIBAPS, Mayo Clinic, IBYME (CONICET), and CaixaResearch Institute demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor—fibroblasts—contributing to their activation.
Activated fibroblasts promote tumor growth and spread, while also conferring resistance to treatments. This may be one of the reasons behind the high aggressiveness of pancreatic cancer, which has a five-year survival rate of only 10%.
The study’s findings open the door to new therapeutic strategies against this type of cancer, focusing on the possibility of inhibiting this protein within the cells that surround and protect the tumor.
Through satellite gravimetry analysis of Antarctic Ice Sheet (AIS) mass changes from 2002 to 2023, striking mass change rates have been identified. The study reveals the most significant mass loss occurred during 2011-2020, primarily driven by accelerated ice loss in Amundsen Sea Embayment, West Antarctica and four key glacier basins in Wilkes Land-Queen Mary Land, East Antarctica. Remarkably, an unprecedented reversal was observed during 2021-2023, with the AIS exhibiting anomalous mass gain - a phenomenon never before recorded in the satellite observation era.
Growing cells in the laboratory is an art that humans have mastered decades ago. Recreating entire three-dimensional tissues is much more challenging. Empa researchers are developing a new hydrogel-based material that makes it possible to engineer artificial skin tissues, which can serve as living three-dimensional models of human skin for better understanding and treating skin diseases.
The origin and the central engine of GRBs have long been pending for identification. Now a joint observation by LEIA and GECAM gives new clues.
Novel physical effects based on chiral structural materials or materials with chiral interactions are being discovered and are becoming the cornerstone for constructing new spintronic devices. A Recent collaborative study published in Science Bulletin discovered a new way to deliberately control spin orientation in a more sophisticated manner. The approach enables the engineered ‘smart’ material, an oxide heterostructure of SrRuO3-SrTiO3, to decide when to halt its spin rotation.
Researchers uncover how over-reducing breast motion in bras could increase back pain during exercise
In a new study, a series of zirconium-based metal-organic frameworks (Zr-MOFs) were successfully synthesized in aqueous environments by researchers, followed by precise enzyme immobilization achieved through ligand-exchange strategies. A fully green technological system spanning material preparation to biocatalyst construction was established, with the developed immobilized enzyme formulations demonstrating remarkable enhancements in both catalytic activity and operational stability.
Access to scientific knowledge is essential for science, as well as for tackling societal challenges. However, the limitation of this access by paywalls comes at a cost to public finances and also, increasingly, to scientific quality. In light of this situation, the authors of a discussion paper published today by the German National Academy of Sciences Leopoldina propose a new funding principle for scientific journals that would make these publications freely available to everyone. Thus, a key aspect is for the funding of journals to follow the same procedure as publicly funded research. This would involve an application process to run a journal as well as regular evaluation. The aim is to guarantee lasting quality, transparency, and scientific relevance while also cutting costs.