Figure 4: Detailed behavioral analysis of BTBR/J and BTBR/R autism model mice (IMAGE)
Caption
a: Open field experiment b. Light-dark box experiment c-e. ultrasonic vocalizations made by mouse pups when separated from the mother. f. ultrasonic vocalizations of adult mice (in the presence of a mouse of the opposite sex). g. Self-grooming behavior. h. Marble burying test. i. 3-chamber social interaction test. j. Barnes maze spatial learning test. BTBR/R and BTBR/J mice share key autistic-like behavioral abnormalities demonstrated in the results for experiments c through i. However, there are differences in anxious behavior (a, b) and spatial learning (j). BTBR/R mice did not demonstrate spatial learning difficulties. Therefore, BTBR/R is a more suitable model of autism than the existing BTBR/J model because it exhibited autistic-like behavior without compromised spatial learning ability.
Credit
Lin, CW., Ellegood, J., Tamada, K. et al. An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development. Mol Psychiatry (2023).
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CC BY