Figure 3: Single-cell RNA analysis of the yolk sac and the AGM region during embryonic development (IMAGE)

Kobe University

Figure 3: Single-cell RNA analysis of the yolk sac and the AGM region during embryonic development

Caption

a. AGM. B. Yolk sac: For BTBR/R autism model mice, genes with increased expression are indicated in pink and genes with decreased expression are in light blue. c-f. Comparison of gene expression levels in each cluster. In BTBR/R mice, there were changes in the expression of various genes (including stress response genes) that are indicative of endogenous retrovirus (ERV) activation.

Credit

Lin, CW., Ellegood, J., Tamada, K. et al. An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development. Mol Psychiatry (2023).

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