Figure 5: Docking model of human CYP enzyme and the chiral PCB CB91 (IMAGE)

Kobe University

Figure 5: Docking model of human CYP enzyme and the chiral PCB CB91

Caption

Light blue indicates substrate-binding cavity inside the CYP enzyme. It is thought that metabolite formation activity is the same for both atropisomers (see Figure 3) because (aR)-CB91 collides with leucine 363 and (aS)-CB91 collides with phenylalanine 206 (collisions indicated by red lines).

Credit

Modified from Inui et al. Environmental Science & Technology, 2022.

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