Figure 4: Docking model of human CYP enzyme and the chiral PCB CB45 (IMAGE)

Kobe University

Figure 4: Docking model of human CYP enzyme and the chiral PCB CB45

Caption

Light blue indicates the substrate-binding cavity inside the CYP enzyme. The CYP enzyme is unable to form a stable interaction with the atropisomer (aS)-CB45 because (aS)-CB45 collides (indicated by the red lines) with leucine 363, therefore CYP produces fewer metabolites (see Figure 3).

Credit

Modified from Inui et al. Environmental Science & Technology, 2022.

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