Activation of Opto-vTrap inhibits evoked EPSC in Schaffer-collateral synapses (IMAGE)

Institute for Basic Science

Activation of Opto-vTrap inhibits evoked EPSC in Schaffer-collateral synapses

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After Opto-vTrap virus injection, evoked excitatory postsynaptic current (EPSC) was measured in mouse brain slices to test whether activation of Opto-vTrap can selectively inhibit synaptic transmission. In the control mouse, no changes in evoked EPSC amplitude before, light on, and after light on conditions were observed. In Opto-vTrap injected brain slices, evoked EPSC amplitude decreased during light on, which promptly recovered after light off.

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Institute for Basic Science

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