(IMAGE) Kumamoto University Caption Dynamic histone code mapping revealed that endothelial cell (EC) activation was triggered by the bivalent epigenome switch which stimulated angiogenesis related acute transferrin (TF) expression. Then, temporal and special coordinate interaction with NFAT/PTIP and the PRC1.3 variant lead proper VEGF-mediated EC activation. Credit Dr. Takashi Minami Usage Restrictions Credit must be given to the creator. License CC BY Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.