(IMAGE)

Kumamoto University

Caption

Kanki, et.al. demonstrate that angiogenesis essential immediate-early genes are silent with canonical PRC-brake in inert endothelium. In a short time, VEGF unlocks the transcription of these genes through bivalent status on the gene loci with PTIP/NFAT, MLL3/4 and noncanonical PRC1.3 accumulation.

Credit

Dr. Takashi Minami

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License

CC BY

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