Effect of <I>Caren</i> RNA Supplement Therapy on Myocardial Cells in Progression of Heart Failure (IMAGE)
Caption
In mice with artificially induced heart failure, the contractility of the heart was markedly reduced after one week which indicated the onset of heart failure. Researchers then administered saline (a; black), a virus that does not affect the amount of Caren RNA (b; green), or a virus that can replenish Caren RNA (c; blue) to the mice that had developed heart failure, and analyzed the changes in cardiac contractility. In the groups that received saline (a; black) and the virus that did not affect the amount of Caren RNA (b; green), the contractility of the heart continued to decrease and heart failure continued to progress. However, in the group that received the Caren RNA replenishing virus (c; blue), decreased heart contractility was suppressed. This suggests that Caren RNA replenishment therapy is effective in suppressing the progression of heart failure.
Credit
Professor Yuichi Oike
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<p>Adapted from Fig. 8d of <a href="https://www.nature.com/articles/s41467-021-22735-7">Sato, M. et.al., Nature Communications, 2021</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>
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