Strategies for Developing New Heart Failure Therapies (IMAGE)
Caption
Caren RNA levels are reduced in the cardiomyocytes of individuals suffering from heart failure. The resulting diminished effects lead to the progression of heart failure pathology. Supplementing cardiomyocytes with Caren RNA increases the number of mitochondria and promotes energy production through improved function. This can then inhibit both the activation of the DNA damage response and the exacerbation of heart failure pathology. Researchers expect this to be a new strategy in the development of heart failure therapies.
Credit
Professor Yuichi Oike
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