N-terminal gasdermin D is increased in preclinical model of ACLF and clinical liver specimens with ACLF (IMAGE)

First Hospital of Jilin University

N-terminal gasdermin D is increased in preclinical model of ACLF and clinical liver specimens with ACLF

Caption

(A) Hepatic protein expression of GSDM-D in healthy, cirrhotic and ACLF mice. (B) Hepatic protein expression of GSDM-D in human specimens from healthy controls and patients with cirrhosis and ACLF. Western blot data were normalised to GAPDH levels. Data are expressed as mean±SD (n=4–5 per group). Statistical significance was determined using one-way analysis of variance: *p<0.05, **p<0.001, ***p<0.0001. ACLF, acute-on-chronic liver failure; BDL, bile duct ligation; EtOH, alcohol; FL-GSDM-D, full-length gasdermin D; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSDM-D, gasdermin D; NT-GSDM-D, N-terminal gasdermin D; RFU, relative fluorescent unit.

Credit

By Martí Ortega-Ribera, Yuan Zhuang, Veronika Brezani, et al.

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License

CC BY-NC

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