Figure 4. Bidirectional regulation of motivation control brain circuits using nano-MIND (IMAGE)
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1. When magnetic stimulation is applied through nano-magnetoreceptors selectively expressed in excitatory or inhibitory neurons of the lateral hypothalamus (LH), bidirectional regulation of brain circuits responsible for motivation and appetite becomes possible.
2. When inhibitory neurons in the LH are selectively activated by nano-MIND, the mouse's appetite and feeding behavior increase twofold. Conversely, when excitatory neurons in the LH are selectively activated by nano-MIND, the mouse's appetite and feeding behavior decrease by more than half.
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