Biogenesis, release and uptake of EVs. (IMAGE)

First Hospital of Jilin University

Biogenesis, release and uptake of EVs.

Caption

EVs are formed by inward budding or endocytosis of the plasma membrane (PM) into the cell. After that, EVs mature gradually and finally are released to extracellular space in the EV generation pathway. Then, EVs enter target cells and interact with them through various mediators such as surface receptors and signalling events in order to influence phenotypes of recipient cells. EVs, extracellular vesicles; ILV, intraluminal vesicle; MVB, multivesicular body; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor.

Credit

By Yingying Liu and Lin Wang

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License

CC BY-NC

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