Therapeutic effects of targeted extracellular vesicles (EVs) in non-parenchymal cells. (IMAGE)

First Hospital of Jilin University

Therapeutic effects of targeted extracellular vesicles (EVs) in non-parenchymal cells.

Caption

After treatments of EVs, proliferation, chemotaxis and profibrogenic signals of activated HSCs decrease while expression of antifibrotic miRNA and apoptosis increase. As for KCs, their polarisation changes and expression of Notch declines while CD73 and CD5L raise. LSECs restore their fenestrae function and therapeutic agent or nanoparticles are allowed to access the space of Disse to play a role. HSC, hepatic stellate cell; KC, Kupffer cell; LSEC, liver sinusoidal endothelial cell; ODN, oligodeoxynucleotide; SMA, smooth muscle actin. 

Credit

By Yingying Liu and Lin Wang

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CC BY-NC

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