A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the National Cancer Institute-funded Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the genes we are born with—known as germline genetic variants—play a powerful, underappreciated role in how cancer develops and behaves. Published in the April 14 online issue of Cell [https://doi.org/10.1016/j.cell.2025.03.026], the study is the first to detail how millions of inherited genetic differences influence the activity of thousands of proteins within tumors. Drawing on data from more than 1,000 patients across 10 different cancer types, the research illustrates how a person’s unique genetic makeup can shape the biology of their cancer.

The team led by Academician Chen Xiaoping from Tongji Hospital, affiliated with the Tongji Medical College of Huazhong University of Science and Technology, in collaboration with several major medical centers, including the Hunan Provincial People's Hospital and the Henan Provincial People's Hospital, conducted a multicenter retrospective study on the controversial issue of whether the caudate lobe of the liver should be routinely resected for patients with hilar cholangiocarcinoma. The results were published in Science China Life Sciences. 

Global disparities exist in the burden of cervical cancer. Only 11 out of the 185 countries and regions reported an age-standardized incidence rates (ASIR) lower than the World Health Organization’s target as established by the Cervical Cancer Elimination Initiative. Human Development Index (HDI) was negatively correlated with ASIR and age-standardized mortality rates (ASMR) of cervical cancer. The disease's burden is marked by clear socioeconomic disparities, underscoring the need to develop and evaluate targeted cervical cancer prevention and control strategies for specific regions.