Virginia Tech researchers developed a saliva-based AI screening method that could flag patients at risk for dangerous side effects from a widely used chemotherapy drug. The drug, 5-fluorouracil (5-FU), has been in use since the 1950s — making it one of the oldest chemotherapy agents still used today. It remains a cornerstone of cancer treatment, used in nearly a third of chemotherapy treatments for colorectal, breast, head and neck, pancreatic, and stomach cancers.