image: New research from Massachusetts General Hospital describes how CD4+ T cells activated by an immune factor called thymic stromal lymphopoietin suppress breast cancer by differentiating cancer into benign cyst-like structures. Here, T cells (yellow) are inducing cyst formation in breast cancer (green), which prevents the cancer cells from proliferating (Ki67 as the marker of cell proliferation, red). view more
Credit: Emanuela Marchese, PhD
Journal
Journal of Experimental Medicine
Method of Research
Experimental study
Subject of Research
Animals
Article Title
CD4+ T helper 2 cells suppress breast cancer by inducing terminal differentiation
Article Publication Date
3-Jun-2022
COI Statement
Disclosures: M. Boieri is an employee of Zelluna Immunotherapy. S. Iyer is an employee of and has equity in Verve Therapeutics. M.N. Rivera reported grants from Advanced Cell Diagnostics and non-financial support from Merck/Serono outside the submitted work. No other disclosures were reported.