Blood sugar levels in response to foods are highly individual

Which is more likely to raise blood sugar levels: sushi or ice cream? According to a Weizmann Institute study reported in the November 19 issue of the journal Cell, the answer varies from one person to another. The study, which continuously monitored blood sugar levels in 800 people for a week, revealed that the bodily response to all foods was highly individual.

The study, called the Personalized Nutrition Project, was conducted by the groups of Prof. Eran Segal of the Computer Science and Applied Mathematics Department and Dr. Eran Elinav of the Immunology Department. Segal said: "We chose to focus on blood sugar because elevated levels are a major risk factor for diabetes, obesity and metabolic syndrome. The huge differences that we found in the rise of blood sugar levels among different people who consumed identical meals highlights why personalized eating choices are more likely to help people stay healthy than universal dietary advice."

Indeed, the scientists found that different people responded very differently to both simple and to complex meals. For example, a large number of the participants' blood sugar levels rose sharply after they consumed a standardized glucose meal, but in many others, blood glucose levels rose sharply after they ate white bread, but not after glucose. Elinav: "Our aim in this study was to find factors that underlie personalized blood glucose responses to food. We used that information to develop personal dietary recommendations that can help prevent and treat obesity and diabetes, which are among the most severe epidemics in human history."

David Zeevi and Tal Korem, PhD students in Segal's lab, led the study. They collaborated with Dr. Niv Zmora, a physician conducting PhD studies in Elinav's lab, and with PhD student Daphna Rothschild and research associate Dr. Adina Weinberger from Segal's lab. The study was unique in its scale and in the inclusion of the analysis of gut microbes, collectively known as the microbiome, which had recently been shown to play an important role in human health and disease. Study participants were outfitted with small monitors that continuously measured their blood sugar levels. They were asked to record everything they ate, as well as such lifestyle factors as sleep and physical activity. Overall, the researchers assessed the response of different people to more than 46,000 meals.

Taking these multiple factors into account, the scientists generated an algorithm for predicting individualized response to food based on the person's lifestyle, medical background, and the composition and function of his or her microbiome. In a follow-up study of another 100 volunteers, the algorithm successfully predicted the rise in blood sugar in response to different foods, demonstrating that it could be applied to new participants. The scientists were able to show that lifestyle also mattered. The same food affected blood sugar levels differently in the same person, depending, for example, on whether its consumption had been preceded by exercise or sleep.

In the final stage of the study, the scientists designed a dietary intervention based on their algorithm; this was a test of their ability to prescribe personal dietary recommendations for lowering blood glucose level responses to food. Volunteers were assigned a personalized "good" diet for one week, and a "bad" diet - also personalized - for another. Both good and bad diets were designed to have the same number of calories, but they differed between participants. Thus, certain foods in one person's "good" diet were part of another's "bad" diet. The "good" diets indeed helped to keep blood sugar at steadily healthy levels, whereas the "bad" diets often induced spikes in glucose levels --all within just one week of intervention. Moreover, as a result of the "good" diets, the volunteers experienced consistent changes in the composition of their gut microbes, suggesting that the microbiome may be influenced by the personalized diets while also playing a role in participants' blood sugar responses.

A video animation describing the study is available at the following link: https://www.youtube.com/watch?v=Ryc5M3Ciytg&feature=youtu.be

The scientists are currently enrolling Israeli volunteers for a longer-term follow-up dietary intervention study that will focus on people with consistently high blood sugar levels, who are at risk of developing diabetes, with the aim of preventing or delaying this disease. To learn more, please visit http://www.personalnutrition.org.

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Also participating in this research were Orly Ben-Yacov, Dar Lador, Dr. Tali Avnit-Sagi, Dr. Maya Lotan-Pompan, Elad Matot, Gal Malka, Noa Kosower, Michal Rein and Rony Bikovsky in Segal's lab; Jotham Suez, Jemal Ali Mahdi, Gili Zilberman-Schapira, Lenka Dohnalova and Dr. Meirav Pevsner-Fischer in Elinav's lab; Dr. David Israeli of the Jerusalem Center for Mental Health; and Prof. Zamir Halpern of the Tel Aviv Sourasky Medical Center.

Prof. Eran Segal's research is supported by the Crown Human Genome Center, which he heads; the Adelis Foundation; the European Research Council; Mr. and Mrs. Donald L. Schwarz, Sherman Oaks, CA; Leesa Steinberg, Canada; and Jack N. Halpern, New York, NY.

Dr. Eran Elinav's research is supported by the Abisch Frenkel Foundation for the Promotion of Life Sciences; the Gurwin Family Fund for Scientific Research; the Leona M. and Harry B. Helmsley Charitable Trust; the Crown Endowment Fund for Immunological Research; the Adelis Foundation; the Rising Tide Foundation; the Vera Rosenberg Schwartz Research Fellow Chair; Yael and Rami Ungar, Israel; John L. and Vera Schwartz, Pacific Palisades, CA; Alan Markovitz, Canada; Leesa Steinberg, Canada; Andrew and Cynthia Adelson, Canada; the estate of Jack Gitlitz; the estate of Lydia Hershkovich; Mr. and Mrs. Donald L. Schwarz, Sherman Oaks, CA; Jack N. Halpern, New York, NY; and Aaron Edelheit, Boca Raton, FL. Dr. Elinav is the Incumbent of the Rina Gudinski Career Development Chair.

The Weizmann Institute of Science in Rehovot, Israel, is one of the world's top-ranking multidisciplinary research institutions. Noted for its wide-ranging exploration of the natural and exact sciences, the Institute is home to scientists, students, technicians and supporting staff. Institute research efforts include the search for new ways of fighting disease and hunger, examining leading questions in mathematics and computer science, probing the physics of matter and the universe, creating novel materials and developing new strategies for protecting the environment.

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