image: In this study we investigated the physiological effects of elevated leptin in lean mice during discrete developmental time periods on subsequent body weight. Male and female mice that were exposed to hyperleptinemia during postnatal nursing period maintained the same body weight as control mice when fed a regular diet. However, when these mice were given free access to a high fat diet, the postnatally hyperleptinemic mice gained more fat than the control mice as adults. Results of this study may have clinical importance in preventing adult obesity by targeting early childhood development. This material relates to a paper that appeared in the Jan. 1, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by A.A. Skowronski at Columbia University Irving Medical Center in New York, NY; and colleagues was titled, "Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice." view more
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