Temporary Leptin Spikes Raise Long-Term Obesity Risk in Baby Mice (1 of 1) (IMAGE)
Caption
In this study we investigated the physiological effects of elevated leptin in lean mice during discrete developmental time periods on subsequent body weight. Male and female mice that were exposed to hyperleptinemia during postnatal nursing period maintained the same body weight as control mice when fed a regular diet. However, when these mice were given free access to a high fat diet, the postnatally hyperleptinemic mice gained more fat than the control mice as adults. Results of this study may have clinical importance in preventing adult obesity by targeting early childhood development. This material relates to a paper that appeared in the Jan. 1, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by A.A. Skowronski at Columbia University Irving Medical Center in New York, NY; and colleagues was titled, "Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice."
Credit
Created with BioRender.com
Usage Restrictions
Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.
License
Licensed content