image: Our findings indicate that NRF2 remodels enhancer landscapes and activates its target genes through a phase-separation mechanism, and that activation of NRF2 represents a promising strategy for restoring redox homeostasis and combatting polycystic kidney disease. This material relates to a paper that appeared in the Jun. 29, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by Y. Lu at Tianjin Medical University in Tianjin, China; and colleagues was titled, "Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease." view more
Credit: [Credit: Lu <i>et al</i>.]