Therapies Restore Antioxidant Protein to Treat Cyst Disorder in the Kidneys of Mice (4 of 4) (IMAGE)

American Association for the Advancement of Science (AAAS)

Therapies Restore Antioxidant Protein to Treat Cyst Disorder in the Kidneys of Mice (4 of 4)

Caption

Our findings indicate that NRF2 remodels enhancer landscapes and activates its target genes through a phase-separation mechanism, and that activation of NRF2 represents a promising strategy for restoring redox homeostasis and combatting polycystic kidney disease. This material relates to a paper that appeared in the Jun. 29, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by Y. Lu at Tianjin Medical University in Tianjin, China; and colleagues was titled, "Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease."

Credit

[Credit: Lu <i>et al</i>.]

Usage Restrictions

Please cite the owner of the material when publishing. This material may be freely used by reporters as part of news coverage, with proper attribution. Non-reporters must contact <i>Science</i> for permission.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.