image: The scientists observed that the transcription factor ATF4 (green) colocalizes with the smooth muscle protein alpha-SMA (red) in myofibroblasts linked to fibrosis. This material relates to a paper that appeared in the May 22, 2019, issue of Science Translational Medicine, published by AAAS. The paper, by B. Selvarajah at University College London in London, UK; and colleagues was titled, "mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis." view more
Credit: B. Selvarajah <em>et al., Science Signaling</em> (2019)