How Production of an Amino Acid Drives Harmful Fibrosis in the Lungs (1 of 1) (IMAGE)

American Association for the Advancement of Science (AAAS)

How Production of an Amino Acid Drives Harmful Fibrosis in the Lungs (1 of 1)

Caption

The scientists observed that the transcription factor ATF4 (green) colocalizes with the smooth muscle protein alpha-SMA (red) in myofibroblasts linked to fibrosis. This material relates to a paper that appeared in the May 22, 2019, issue of Science Translational Medicine, published by AAAS. The paper, by B. Selvarajah at University College London in London, UK; and colleagues was titled, "mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis."

Credit

B. Selvarajah <em>et al., Science Signaling</em> (2019)

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