image: Design and structure of the device with photos of the device geometrical changes with controllable length/diameter ratio (left). Magnetic resonance black-blood thrombus imaging showed a significant reduction in thrombus volume before and after thrombectomy and complete recanalization of the occluded vessel (right).
Credit: Xuanwu Hospital, Capital Medical University
Cerebral venous sinus thrombosis (CVST) is a neurological condition that disproportionately affects younger adults, characterized by large thrombus volumes. The unique anatomical features of the superior sagittal sinus, such as its triangular cross-sectional shape and large diameter, pose significant challenges for thrombectomy procedures. Conventional artery stent retrievers are ill-suited for venous vessels due to these anatomical differences. A research team led by Prof. Xunming Ji from Xuanwu Hospital of Capital Medical University has developed a dumbbell-shaped thrombectomy device, offering a novel solution for CVST treatment, which has been published in National Science Review.
The device is fabricated by NiTi alloy wire 3D weaving technology, which can be manually rotated and stretched, and the length/diameter ratio is controlled between 2.6 and 14.0, providing reciprocating control. This design allows for precise control during the thrombectomy procedure, crucial for navigating the complex venous anatomy and effectively removing thrombi.
The mechanical properties of the device were thoroughly evaluated through computational modeling and in vitro studies, ensuring its safety and efficacy. The ability of device to trap and remove thrombi from occluded venous vessels was verified using a swine model, demonstrating its practical application potential. Furthermore, a single-center retrospective clinical study involving 10 patients treated with the Venus-TD device showed a significant reduction in thrombus volume with a high recanalization rate and favorable clinical outcomes.
This study represents a significant advancement in the treatment of extensive CVST, offering a novel and effective treatment option for patients suffering from this condition. The dumbbell-shaped thrombectomy device with controllable axial and longitudinal maneuverability has the potential to improve clinical outcomes and quality of life for patients with CVST. This innovation could pave the way for further advancements in neurointerventional devices, offering new hope for patients suffering from CVST.