miR-618 rs2682818 C>A polymorphism decreases neuroblastoma risk in tumors originating from the adrenal gland

Background and objectives

MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression by either degrading or inhibiting the translation of mRNAs and have significant roles in the development of various tumors. A polymorphism (rs2682818) in miR-618 has been confirmed to be correlated with susceptibility to various cancers. Nonetheless, its role has not been investigated in neuroblastoma to date. Therefore, we assessed whether the miR-618 rs2682818 C>A polymorphism was correlated with neuroblastoma risk in the Chinese population.

Methods

We performed this case-control study with 402 neuroblastoma patients and 473 cancer-free controls from Jiangsu Province, China. The TaqMan method was used to genotype the miR-618 rs2682818 polymorphism. We evaluated the strength of the correlation between this polymorphism and susceptibility to neuroblastoma based on the odds ratios (ORs) and 95% confidence intervals (CIs), which were calculated by logistic regression models.

Results

Overall, no significant correlation was observed between the rs2682818 C>A polymorphism and the risk of neuroblastoma. Nevertheless, we conducted a further stratification analysis and discovered that, compared to the CC genotype of rs2682818, the subjects with CA/AA genotypes had a lower risk to neuroblastoma developing in the adrenal gland (adjusted OR = 0.57, 95% CI: 0.35–0.91, p = 0.018).

Conclusions

In summary, the miR-618 rs2682818 C>A polymorphism was significantly associated with decreased risk of neuroblastoma in tumors originating from the adrenal gland. Our findings indicate that miR-618 rs2682818 may be a neuroblastoma susceptibility gene. Large multiregional and multicenter studies with populations of various ethnicities are required to verify our results.

Full text

https://www.xiahepublishing.com/2835-3315/CSP-2023-00035

The study was recently published in the Cancer Screening and Prevention.

Cancer Screening and Prevention (CSP) publishes high-quality research and review articles related to cancer screening and prevention. It aims to provide a platform for studies that develop innovative and creative strategies and precise models for screening, early detection, and prevention of various cancers. Studies on the integration of precision cancer prevention multiomics where cancer screening, early detection and prevention regimens can precisely reflect the risk of cancer from dissected genomic and environmental parameters are particularly welcome.

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