image: Figure 1. Analysis of the levels of t-Cys residues in the circulating blood plasma platelet proteome of young and old subjects. (A) Average level of t-Cys residues in proteins, categorized by age group. (B) Functional enrichment of differentially expressed peptides featuring t-Cys modification grouped by protein and age. Proteins exhibiting notably greater levels in older individuals as compared to their younger counterparts are depicted as blue dots. The size of the biological process dots corresponds to the differential number of t-Cys proteins incorporated. Significance was established at p<0.05, and the error bars in the graphs represent the SEM.
Credit: Sánchez Milán et al.
“The results indicated a significant increase in cumulative t-Cys levels and the total number of t-Cys residues in aging and aged mice proteomes compared to young groups.”
BUFFALO, NY- August 27, 2024 – A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 15 on July 25, 2024, entitled, “Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms.”
Oxidative stress (OS) - characterized by an imbalance between oxidants and antioxidants - leads to the formation of oxidative posttranslational modifications (PTMs), including those involving cysteine (Cys) residues in aging proteomes. Specifically, the formation of trioxidized Cys (t-Cys) results in permanent protein damage. Recent findings in rodents have revealed that irregular regulation of t-Cys residues in the aging proteome disrupts homeostatic phosphorylation signaling, leading to alterations in proteins similar to those caused by phosphorylated serine (p-Ser) residues.
In this perspective, researchers José Antonio Sánchez Milán, María Mulet, Aida Serra and Xavier Gallart-Palau from University Hospital Arnau de Vilanova (HUAV) and University of Lleida (UdL), present novel data, validating the increase of specific t-Cys sites associated with aging in a blood-related circulating human proteome.
"The scope and findings included here support the hypothesis that t-Cys residues may serve as important mechanistic and biological markers, warranting further exploration in the context of unhealthy aging and age-related major diseases.”
Continue reading: DOI: https://doi.org/10.18632/aging.206036
Correspondence Authors: Aida Serra - aida.serra@udl.cat, and Xavier Gallart-Palau - xgallart@irblleida.cat
Video short: https://www.youtube.com/watch?v=roO_8WMGak8
Keywords: oxidative stress, unhealthy aging, t-Cys, aging diseases, aging proteome
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The journal Aging aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)
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Journal
Aging-US
Method of Research
News article
Subject of Research
Not applicable
Article Title
Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms
Article Publication Date
25-Jul-2024
COI Statement
The authors assert that they possess no conflicting interests with respect to the information and findings disclosed. The interpretations presented in this work are founded on the knowledge of the authors and scientific data collected and are those of the authors, not necessarily those of the governmental organizations that financed the study.