Trioxidized cysteine and aging: a molecular binomial that extends far beyond classical proteinopathic paradigms (IMAGE)
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Figure 1. Analysis of the levels of t-Cys residues in the circulating blood plasma platelet proteome of young and old subjects. (A) Average level of t-Cys residues in proteins, categorized by age group. (B) Functional enrichment of differentially expressed peptides featuring t-Cys modification grouped by protein and age. Proteins exhibiting notably greater levels in older individuals as compared to their younger counterparts are depicted as blue dots. The size of the biological process dots corresponds to the differential number of t-Cys proteins incorporated. Significance was established at p<0.05, and the error bars in the graphs represent the SEM.
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Sánchez Milán et al.
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