News Release

During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered

Promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity

Peer-Reviewed Publication

PLOS

During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered

image: C. elegans head/upper body with aggregates (KIN-19) in the pharynx in control conditions (left) and without aggregates upon proteasome inhibition (right photo). view more 

Credit: Raimund Jung (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)

During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity.

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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002284

Article Title: A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans

Author Countries: Germany, United Kingdom

Funding: see manuscript

Journal

PLOS Biology

DOI

10.1371/journal.pbio.3002284

COI Statement

Competing interests: The authors have declared that no competing interests exist.

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