克隆胚胎围着床期发育异常的障碍机制。 (IMAGE) Science China Press Caption 模式图显示在植入前阶段克隆胚胎的谱系特化重编程有缺陷。Wnt通路的持续激活阻碍了围着床期外胚层细胞多能性状态的转变及H3K27me3修饰的重塑过程,从而诱发外胚层组织的无序生长及植入失败。外源操纵Wnt抑制能够驱动外胚层多能性转变,最终可提升克隆胚胎围着床期发育潜能。 Credit ©《中国科学》杂志社 Usage Restrictions Use with credit. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.