The barrier mechanism of abnormal peri-implantation development of cloned embryos (IMAGE)
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A schematic model showing the defective lineage specification reprogramming in SCNT embryos at the preimplantation stage. Persistent Wnt activity blocks the naïve-to-primed pluripotency transition of epiblast in peri-implantation cloned embryos, which accompanied by the aberrant H3K27me3 reprogramming. The barriers can result in the epiblast disorganization and implantation failure. Wnt manipulation can drive pluripotency transitions of epiblast cells to a considerable degree, further improving the peri-implantation development of cloned embryos.
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