Severe ARIA-E (edema) in a 69-year-old woman receiving aducanumab therapy for AD with headaches and word-finding difficulty. (IMAGE)
Caption
Severe ARIA-E (edema) in a 69-year-old woman receiving aducanumab therapy for AD with headaches and word-finding difficulty. (A, B) Axial MR images of the brain show multifocal subcortical edema (arrows) with FLAIR hyperintensity (A) and increased diffusion on the apparent diffusion coefficient (ADC) map (B), with a few areas measuring more than 10 cm. (C) Axial follow-up MR image 4 months later shows near-complete resolution of signal intensity changes. ARIA-E is most common in the occipital lobes (as in this case) and mimics posterior reversible encephalopathy syndrome (PRES) at imaging. (A, B) Axial MR images of the brain show multifocal subcortical edema (arrows) with FLAIR hyperintensity (A) and increased diffusion on the apparent diffusion coefficient (ADC) map (B), with a few areas measuring more than 10 cm. (C) Axial follow-up MR image 4 months later shows near-complete resolution of signal intensity changes. ARIA-E is most common in the occipital lobes (as in this case) and mimics posterior reversible encephalopathy syndrome (PRES) at imaging.
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Radiological Society of North America
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