Figure 1 (IMAGE)
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Metabolic phenotype affected by aging and adipocyte-specific Crtc2 knockout. Adipocyte-specific Crtc2 knockout mice (Crtc2 AKO) confirmed a suppression of impaired glucose tolerance (A) and an increase in fat mass (B) caused by aging. Moreover, Crtc2 AKO mice exhibited a significant reduction in fat accumulation in the liver and adipose tissues due to aging (C).
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