A Genetically Encoded Light-inducible CaMKII Inhibitor, paAIP2 (IMAGE)

Max Planck Florida Institute for Neuroscience

A Genetically Encoded Light-inducible CaMKII Inhibitor, paAIP2

Caption

This is a schematic of paAIP2. LOV2-Jα domain derived from phototropin1 was fused to autocamtide-2 related inhibitory peptide 2 (AIP2). The blue light absorption causes a reversible conformational change of LOV2 domain, leading to dissociation of the Jα helix-AIP2. The structurally released AIP2 binds to the kinase domain of CaMKII and inhibits its kinase activity.

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Max Planck Florida Institute for Neuroscience

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