Fig.1 MIB2 blocks caspase 8 activation through ubiquitylation of cFLIP (IMAGE)

Toho University

Fig.1 MIB2 blocks caspase 8 activation through ubiquitylation of cFLIP

Caption

MIB2 constitutively binds and ubiquitylates cFLIP. Upon TNF stimulation, caspase 8 and ubiquitylated cFLIP are recruited to the death-inducing complex. Ubiquitylated cFLIP prevents a proper oligomer formation with caspase 8, thereby suppressing caspase 8 activation and apoptosis.

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Hiroyasu Nakano

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